STM32L452RET6 ST Mainstream Arm Cortex-M4 Ultra-Low-Power 32-bit MCU 512KB Flash 160KB SRAM USB DAC Comparator LQFP-64

STM32L452RET6 Product Overview

STM32L452RET6 is an Arm Cortex-M4 MCU at 80 MHz with FPU and ART Accelerator, LQFP-64. 512 KB Flash, 160 KB SRAM, USB 2.0 FS device (crystal-less), 12-bit ADC (16 ch), 12-bit DAC, two comparators, LP timers, RTC, 2×USART, 1×UART, 1×LPUART, 2×SPI/I2S, 4×I2C. Up to 52 x 5 V-tolerant I/Os. 1.71–3.6 V, -40–85 °C. Compared to the STM32L452RCT6 (256 KB Flash), the STM32L452RET6 doubles the Flash to 512 KB, offering an even more spacious ultra-low-power platform for battery-powered IoT nodes, portable instruments, and industrial sensors needing larger program storage, USB communication, and rich peripheral connectivity.

STM32L452RET6 Core Features

Core: The STM32L452RET6 features an Arm Cortex-M4 core at 80 MHz, with FPU + ART Accelerator

Memory: The STM32L452RET6 provides 512 KB Flash and 160 KB SRAM, offering ample space for complex firmware and data buffering

USB: The STM32L452RET6 integrates a USB 2.0 FS device (crystal-less)

Analog: 12-bit ADC (16 ch), 12-bit DAC, 2×Comparators

Connectivity: 2×USART, 1×UART, 1×LPUART, 2×SPI/I2S, 4×I2C

Timers: Advanced Timer, GP/LP Timers, RTC

I/Os: 52 (5 V-tolerant)

Package: LQFP-64

Temperature Range: -40°C to 85°C

STM32L452RET6 Applications

IoT Sensor Nodes: Battery-powered wireless sensors and USB data acquisition modules can leverage the STM32L452RET6's low power and connectivity

Portable Devices: Wearables, portable medical devices, and USB peripherals benefit from the STM32L452RET6's compact integration

Industrial Metering: Water, gas, and electricity meters are ideal applications for the STM32L452RET6

Consumer Electronics: Remote controls, e-labels, smart cards

Low-Power Systems Needing USB, Large RAM & Large Flash: Portable data loggers and handheld measurement devices can rely on the STM32L452RET6's generous memory

STM32L452RET6 Key Advantages

512 KB Flash + 160 KB SRAM: The STM32L452RET6 delivers a massive memory combination for complex programs and large data buffering

Cortex-M4 + FPU + Ultra-Low Power: The STM32L452RET6 achieves excellent DSP and floating-point performance while maintaining extremely low power consumption

Integrated Crystal-less USB: The STM32L452RET6 enables USB communication without an external crystal, simplifying design and saving BOM

On-Chip DAC & Dual Comparators: The STM32L452RET6 offers flexible analog output and signal threshold detection without external components

52 I/Os + LPUART + Multiple I2C: The STM32L452RET6 provides rich peripheral connectivity for multi-sensor systems

5 V-tolerant I/Os: Enhanced system noise immunity, simplified external level-shifting circuitry

Full Ecosystem Compatibility: Easy development with STM32CubeIDE/HAL/LL libraries for the STM32L452RET6

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FAQ

1. What is STM32L452RET6?
STM32L452RET6 is an ultra-low-power 32-bit MCU from STMicroelectronics' STM32L4 series, built around an Arm® Cortex®-M4 core with FPU and DSP instructions in an LQFP-64 package. Operating at 80 MHz, the STM32L452RET6 provides 512 KB Flash and 160 KB SRAM—offering more on-chip RAM than many other L4 devices—making it particularly well suited for battery-powered applications that need larger data buffers or complex algorithm execution.

2. What are the key specifications of STM32L452RET6?

• Core: Arm® Cortex®-M4, up to 80 MHz, 100 DMIPS with FPU and DSP

• Memory: 512 KB Flash, 160 KB SRAM

• Operating Voltage: 1.71 V to 3.6 V

• Temperature Range: -40 °C to +85 °C (industrial grade)

• I/O Count: up to 52

• Package: LQFP-64 (10 mm × 10 mm)

3. Is the STM32L452RET6 package easy to solder?
The STM32L452RET6 uses an LQFP-64 package measuring 10 mm × 10 mm with exposed 0.5 mm pitch leads. Drag-soldering the STM32L452RET6 with a standard soldering iron and flux is straightforward—no hot-air station required—making it very suitable for hand assembly, small-batch production, and rapid prototyping.

4. What applications is STM32L452RET6 suitable for?
With 160 KB of SRAM, a CAN 2.0B bus, USB OTG, and rich high-precision analog peripherals, the STM32L452RET6 is ideal for battery-powered devices needing generous data buffering, such as industrial sensor data concentrators, portable audio processing terminals, complex control algorithm nodes, and IoT edge devices that require both communication bandwidth and ample memory capacity.

5. What development tools support STM32L452RET6?
ST provides free STM32CubeMX for graphical configuration and STM32CubeIDE as an integrated development environment for the STM32L452RET6, along with the STM32CubeL4 firmware library. Debugging and programming are handled by ST-Link debuggers. The pin-compatible NUCLEO-L452RE board offers an excellent starting point for prototyping and code migration.

6. What is the power consumption of the STM32L452RET6 across its low-power modes?

• Temperature Range: -40 °C to +85 °C

• Ultra-low-power modes of the STM32L452RET6:

  • Shutdown mode: ~33 nA (5 wake-up pins)

  • Standby mode: ~125 nA (5 wake-up pins), ~430 nA with RTC

  • Stop 2 mode: ~1.2 µA, ~1.4 µA with RTC

  • Run mode: ~100 µA/MHz (LDO mode)

7. The STM32L452RET6 has 160 KB SRAM compared to 128 KB on the L476/L471. What practical benefit does the extra 32 KB provide?
The additional 32 KB of SRAM on the STM32L452RET6 enables deeper buffers for communication stacks, more complex DSP algorithms, or larger frame buffers for display applications. For systems that need to run an RTOS alongside multiple communication tasks and signal processing pipelines, the extra on-chip RAM reduces reliance on external memory, lowering overall power consumption and PCB footprint.

8. What key peripheral interfaces does STM32L452RET6 offer?

• Communication: CAN 2.0B, I²C, SPI, UART/USART, USB OTG FS, SAI (I2S/PCM/PDM)

• Analog: 12-bit 5 Msps ADC, 12-bit DAC, ultra-low-power comparators, operational amplifiers

• Timers: 16-bit and 32-bit general-purpose timers, advanced motor-control timer

• Others: Quad SPI interface, SDMMC interface

9. How does STM32L452RET6 differ from STM32L476RET6?
Both share an LQFP-64 package, 80 MHz Cortex-M4 core, and 512 KB Flash. The most notable differences are that the STM32L452RET6 provides 160 KB SRAM (32 KB more than the L476) and integrates operational amplifiers. However, it lacks the segment LCD driver found on the L476. If your application doesn't need a segment display but benefits from larger memory and analog signal conditioning, the STM32L452RET6 is the better fit.

10. What is the difference between STM32L452RET6 and STM32L471RET6?
Both are LQFP-64 devices with 512 KB Flash. The STM32L452RET6 features 160 KB SRAM—32 KB more than the L471—and includes integrated operational amplifiers for direct weak-signal conditioning. Neither has a segment LCD driver, and both provide CAN 2.0B and USB OTG. The STM32L452RET6 is ideal for applications that need the extra on-chip memory and a more integrated analog front end.