STM32L452CEU6 ST Mainstream Arm Cortex-M4 Ultra-Low-Power 32-bit MCU 512KB Flash 160KB SRAM USB DAC Comparator UFQFPN-48

STM32L452CEU6 Product Overview

STM32L452CEU6 is an Arm Cortex-M4 MCU at 80 MHz with FPU and ART Accelerator, UFQFPN-48. 512 KB Flash, 160 KB SRAM, USB 2.0 FS device (crystal-less), 12-bit ADC (10 ch), 12-bit DAC, two comparators, LP timers, RTC, 2×USART, 1×UART, 1×LPUART, 2×SPI/I2S, 4×I2C. Up to 38 x 5 V-tolerant I/Os. 1.71–3.6 V, -40–85 °C. Compared to the L451 series, the STM32L452CEU6 adds a crystal-less USB interface while retaining the large SRAM, making it a highly competitive ultra-low-power platform for battery-powered IoT nodes, portable devices, and sensor applications requiring both large data buffering and USB communication.

STM32L452CEU6 Core Features

Core: The STM32L452CEU6 features an Arm Cortex-M4 core at 80 MHz, with FPU + ART Accelerator

Memory: The STM32L452CEU6 provides 512 KB Flash and 160 KB SRAM, offering ample space for complex firmware and data buffering

USB: The STM32L452CEU6 integrates a USB 2.0 FS device (crystal-less)

Analog: 12-bit ADC (10 ch), 12-bit DAC, 2×Comparators

Connectivity: 2×USART, 1×UART, 1×LPUART, 2×SPI/I2S, 4×I2C

Timers: Advanced Timer, GP/LP Timers, RTC

I/Os: 38 (5 V-tolerant)

Package: UFQFPN-48

Temperature Range: -40°C to 85°C

STM32L452CEU6 Applications

IoT Sensor Nodes: Battery-powered wireless sensors and USB data acquisition modules can leverage the STM32L452CEU6's low power and connectivity

Portable Devices: Wearables, portable medical devices, and USB peripherals benefit from the STM32L452CEU6's compact integration

Industrial Metering: Water, gas, and electricity meters are ideal applications for the STM32L452CEU6

Consumer Electronics: Remote controls, e-labels, smart cards

Low-Power Applications Needing USB & Large RAM: Portable data loggers and handheld measurement devices can rely on the STM32L452CEU6's generous memory

STM32L452CEU6 Key Advantages

512 KB Flash + 160 KB SRAM: The STM32L452CEU6 delivers a massive memory combination for complex programs and large data buffering

Cortex-M4 + FPU + Ultra-Low Power: The STM32L452CEU6 achieves excellent DSP and floating-point performance while maintaining extremely low power consumption

Integrated Crystal-less USB: The STM32L452CEU6 enables USB communication without an external crystal, simplifying design and saving BOM

On-Chip DAC & Dual Comparators: The STM32L452CEU6 offers flexible analog output and signal threshold detection without external components

LPUART Low-Power Serial + 4×I2C: Rich low-power communication interfaces for flexible connectivity

Ultra-Compact UFQFPN-48 Package: Significantly reduces PCB area while retaining 38 I/Os

5 V-tolerant I/Os: Enhanced system noise immunity, simplified external level-shifting circuitry

Full Ecosystem Compatibility: Easy development with STM32CubeIDE/HAL/LL libraries for the STM32L452CEU6

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FAQ

1. What is STM32L452CEU6?
STM32L452CEU6 is an ultra-low-power 32-bit MCU from STMicroelectronics' STM32L4 series, built around an Arm® Cortex®-M4 core with FPU and DSP instructions in a UFQFPN-48 package (7 mm × 7 mm). Operating at 80 MHz, the STM32L452CEU6 packs 512 KB Flash and 160 KB SRAM along with CAN 2.0B, USB OTG, SAI audio interface, and operational amplifiers into an extremely compact footprint—ideal for highly integrated, space-constrained battery-powered devices.

2. What are the key specifications of STM32L452CEU6?

• Core: Arm® Cortex®-M4, up to 80 MHz, 100 DMIPS with FPU and DSP

• Memory: 512 KB Flash, 160 KB SRAM

• Operating Voltage: 1.71 V to 3.6 V

• Temperature Range: -40 °C to +85 °C (industrial grade)

• I/O Count: up to 38

• Package: UFQFPN-48 (7 mm × 7 mm)

3. What are the characteristics of the UFQFPN-48 package on the STM32L452CEU6, and is it easy to solder?
The UFQFPN-48 is an ultra-thin QFN package measuring only 7 mm × 7 mm with an exposed thermal pad underneath. All pins of the STM32L452CEU6 are located on the bottom side, requiring reflow soldering or a hot-air station for assembly—manual soldering with a conventional iron is not feasible. This package drastically saves PCB space but demands precise stencil design and controlled reflow profiles, making the STM32L452CEU6 well-suited for automated SMT production.

4. What applications is STM32L452CEU6 suitable for?
Thanks to its ultra-compact 48-pin package, 512 KB Flash, 160 KB SRAM, and rich peripherals including CAN, USB OTG, and op-amps, the STM32L452CEU6 is ideally suited for size- and power-critical designs such as wearables, portable medical terminals, miniature drone flight controllers, industrial sensor modules, and IoT nodes that need to integrate a full control system and communication interfaces in the smallest possible footprint.

5. What development tools support STM32L452CEU6?
ST provides free STM32CubeMX for graphical configuration and STM32CubeIDE as an integrated development environment for the STM32L452CEU6, along with the STM32CubeL4 firmware library. Debugging and programming are handled by ST-Link debuggers. For rapid prototyping, the NUCLEO-L452RE board (LQFP-64 package) can serve as a functional reference, or QFN adapter boards can be used for early-stage verification of the STM32L452CEU6 variant.

6. What is the power consumption of the STM32L452CEU6 across its low-power modes?

• Temperature Range: -40 °C to +85 °C

• Ultra-low-power modes of the STM32L452CEU6:

  • Shutdown mode: ~33 nA (5 wake-up pins)

  • Standby mode: ~125 nA (5 wake-up pins), ~430 nA with RTC

  • Stop 2 mode: ~1.2 µA, ~1.4 µA with RTC

  • Run mode: ~100 µA/MHz (LDO mode)

7. How does STM32L452CEU6 differ from STM32L452RET6 (LQFP-64)?
Both share the same core, 512 KB Flash, 160 KB SRAM, and full peripheral set (CAN, USB, SAI, op-amps, etc.). The only differences are the package and I/O count: the STM32L452CEU6 uses a 48-pin UFQFPN package with up to 38 I/Os, while RET6 uses a 64-pin LQFP with up to 52 I/Os. The STM32L452CEU6 is ideal for designs where PCB area is the primary constraint, whereas RET6 offers more I/O flexibility and easier hand-soldering.

8. What key peripherals remain available on the 48-pin STM32L452CEU6?
Despite the reduced pin count, nearly all core peripherals are still accessible on the STM32L452CEU6, including CAN 2.0B, USB OTG FS, SAI audio interface, 12-bit 5 Msps ADC, DAC, operational amplifiers, and Quad SPI. Some peripheral functions may compete for the same pins through multiplexing, but flexible pin mapping on the STM32L452CEU6 allows complex functionality to be implemented even in this miniature form factor.

9. How does STM32L452CEU6 differ from STM32L476CEU6?
Both are 48-pin devices with an 80 MHz Cortex-M4 core. The STM32L452CEU6 features larger SRAM (160 KB vs 128 KB) and includes integrated operational amplifiers, while the L476CEU6 offers a segment LCD driver. Both have CAN 2.0B. If your design does not need a segment display but benefits from more RAM and built-in analog signal conditioning, the STM32L452CEU6 is the superior choice.

10. How can I fully leverage the 160 KB SRAM on the STM32L452CEU6 in such a small package?
The 160 KB of SRAM on the STM32L452CEU6 can accommodate generous RTOS task stacks and communication buffers, as well as handle complex data processing algorithms such as digital filtering and sensor fusion. In a miniature device, having sufficient on-chip memory eliminates the need for external SRAM or PSRAM, further reducing component count, lowering power consumption, and simplifying PCB layout to keep the end product as compact as possible. The STM32L452CEU6's generous SRAM is a key enabler for complex functionality in space-constrained designs.